Key words
Objectives
The everyday (bio)chemistry has often to deal with (mixtures of) more or
less complex compounds. Optimizing chemical processes, conditions, products,
materials, ... needs, in most cases, the knowledge of the qualitative (and
quantitative) composition and/or the precise chemical structure of the
components.
In the course "spectroscopic techniques" the most important qualitative
methods for the identification of, most of all, organic compounds are
discussed. The theoretical part explains the (physico-)chemical base and
background. In the practical (theoretical) exercises the structural
characteristics of a number of unknown elements is deduced from the spectra,
using specific tables. Finally the students must be able to find the
chemical structure of a compound from the combined UV-, IR-, NMR- and
MS-spectra, possible in connection with known chemical and physical
properties.
Topics
Part 1: theoretical session
Introduction to spectroscopy, absorption and Raman spectra;
Vibrational- and rotational spectroscopy, (near-IR spectroscopy);
Ultraviolet and visible spectroscopy;
Fluorescence and phosphorescence spectroscopy, "liquid scintillation
counting";
Nuclear magnetic resonance spectroscopy (1H and 13C);
Mass spectroscopy.
Part 2: practical session
Interpretation of UV, VIS, IR, NMR and MS spectra (if necessary, completed
with physical and chemical information of the unknown); computer simulation
of spectra;
Demonstrations are given of the sample preparation and the registration of
the spectra on available equipment.
Prerequisites
The students must have a sufficient knowledge of the general, inorganic and
organic chemistry.
Final Objectives
Materials used
Teacher's courses, based on "spectroscopische technieken", H.E. Hilderson,
IHR-CTL, 1990, in agreement with the author. Additional notes and background
information given during the lectures, also belong to the examination
subject.
Textbooks for optional background information:
* "Physical Chemistry", P.W.Atkins; Oxford University Press, 1999.
* "Spectroscopic Methods in Organic Chemistry", Williams and Fleming;
McGraw-Hill, 1995.
"Principles of Instrumental Analysis", Skoog e.a.; Saunders College Publi, 1998
Study costs
Study guidance
Teaching Methods
Contacting hours: lectures (theoretical session); demonstrations and guided
theoretical exercises (practical session);
Home study: It's expected that the students perform, on an individual basis,
the additional theoretical exercises, found after each chapter.
Nevertheless, supplementary explanation can be obtained by appointment.
Assessment
Part 1: theoretical session: written examination with oral explanation (open
questions concerning the course and the additional notes) (57÷).
Part 2: practical session: permanent evaluation and written tests on the
interpretation of spectra (43÷)
Lecturer(s)
Paul VANHEE
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